Hematological ratios as markers of lupus activity in Paraguayan patients with systemic lupus erythematosus

Autores/as

  • Zoilo Morel Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay
  • Rodrigo Acosta Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay
  • Astrid Paats Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay
  • Sonia Cabrera Villalba Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay https://orcid.org/0000-0001-6224-2679
  • Paloma de Abreu Sociedad Paraguaya de Reumatología, Paraguay https://orcid.org/0000-0002-2076-8258
  • Gabriela Avila Pedretti Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay
  • Osmar Antonio Centurion Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay
  • María Eugenia Acosta Universidad Nacional de Asunción, Instituto de Investigación en Ciencias de la Salud, Laboratorio de Genética Molecular, San Lorenzo, Paraguay https://orcid.org/0000-0003-0801-4397
  • María Teresa Martinez de Filartiga Laboratorio Curie, Asunción, Paraguay
  • Yurilis Fuentes Silva Universidad de Oriente, Departamento de Medicina, Ciudad Bolívar, Venezuela https://orcid.org/0000-0002-5915-769X
  • Isabel Acosta Colman Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay https://orcid.org/0000-0001-7296-5950

DOI:

https://doi.org/10.52379/mcs.v8i3.437

Palabras clave:

Systemic lupus erythematosus (SLE), Neutrophil/lymphocyte ratio, Platelet/lymphocyte ratio, Eosinophil/lymphocyte ratio, Monocyte/Lymphocyte ratio

Resumen

Introduction: The neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) are markers of inflammation and prognosis in systemic diseases. This study determined the association between hematological indices, and disease activity in patients with systemic lupus erythematosus (SLE). Methods: This prospective, observational and analytical cross-sectional study included 87 Paraguayan patients diagnosed with SLE, according to the ACR/EULAR 2019 criteria. We investigate four hematological indices: neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), eosinophil/lymphocyte ratio (ELR), and monocytes/lymphocyte ratio (MLR). Results: Eighty-seven percent were female, with a median age of 34.9 ±12.3 years. SLEDAI mean of 3.68 ± 4.76 was found. SLEDAI mean was 3.68 ± 4.76. Positivity of anti-DNAds was found in 52% of the patients. CRP mean was 3.5 ± 4.6. Regarding values of hematological indices, we found: NLR mean of 2.4 ± 1.6 was obtained, ELR 0.07 ± 0.09, MRL 0.07 ± 0.07 and PLR 155.89 ± 80.69. A significant positive correlation was found with SLEDAI and NLR (r=0.34, p=0.001). Based on the ROC curve, the best cut-off value for our patient cohort capable of predicting patients with high activity is for NLR values ? 2.283 (AUC: 0.66). Conclusion: NLR could be a valuable and accessible biomarker to identify elevated activity in patients with SLE.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

REFERENCES

Rebak J, Yucra D, Brigante J, Hamaui A, Dubinsky D. Neutropenia al diagno?stico de lupus eritematoso siste?mico: prevalencia y correlaciones cli?nicas y serolo?gicas: Nuestra cohorte. Rev. Argent. Reumatol. 2022;33(2):76 -82. https://doi.org/10.47196/rar.v33i2.609

Kandane-Rathnayake R, Louthrenoo W, Golder V, Luo SF, Wu YJJ, Lateef A, & Asia Pacific Lupus Collaboration. Independent associations of lymphopenia and neutropenia in patients with systemic lupus erythematosus: a longitudinal, multinational study. Rheumatology.2021; 60(11):5185-5193. https://doi.org/10.1093/rheumatology/keab217

Carli L, Tani C, Vagnani S, Signorini V, Mosca M. Leukopenia, lymphopenia, and neutropenia in systemic lupus erythematosus: Prevalence and clinical impact--A systematic literature review. Semin Arthritis Rheum. 2015;45(2):190-194. https://doi.org/10.1016/j.semarthrit.2015.05.009

Rivero SJ, Díaz-Jouanen E, Alarcón-Segovia D. Lymphopenia in systemic lupus erythematosus. Clinical, diagnostic, and prognostic significance. Arthritis Rheum. 1978;21(3):295-305. https://doi.org/10.1002/art.1780210302

Liu J, Ao W, Zhou J, Luo P, Wang Q, Xiang D. The correlation between PLR-NLR and prognosis in acute myocardial infarction. Am J Transl Res. 2021;13(5):4892-4899. URL

Maravilla Domínguez MA, Zermeño González ML, Zavaleta Muñiz ER, Montes Varela VA, Irecta Nájera CA, Fajardo Robledo NS, et al. Inflammation and atherogenic markers in patients with type 2 diabetes mellitus. Clin Investig Arterioscler. 2022;34(3):105-112. https://doi.org/10.1016/j.arteri.2021.03.006

Feng JF, Huang Y, Chen QX. Preoperative platelet lymphocyte ratio (PLR) is superior to neutrophil lymphocyte ratio (NLR) as a predictive factor in patients with esophageal squamous cell carcinoma. World J Surg Oncol. 2014;12:58. https://doi.org/10.1186/1477-7819-12-58

Erre GL, Paliogiannis P, Castagna F, Mangoni AA, Carru C, Passiu G, et al. Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis. Eur J Clin Invest. 2019;49(1):e13037. https://doi.org/10.1111/eci.13037

Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H, et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26(3):372-6. https://doi.org/10.3109/14397595.2015.1091136

Suszek D, Górak A, Majdan M. Differential approach to peripheral blood cell ratios in patients with systemic lupus erythematosus and various manifestations. Rheumatol Int. 2020;40(10):1625-1629. https://doi.org/10.1007/s00296-020-04669-3

Wang L, Wang C, Jia X, Yang M, Yu J. Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis. Clinics (Sao Paulo). 2020;75:e1450. https://doi.org/10.6061/clinics/2020/e1450

Yu J, Zeng T, Wu Y, Tian Y, Tan L, Duan X, et al. Neutrophil-to-C3 ratio and neutrophil-to-lymphocyte ratio were associated with disease activity in patients with systemic lupus erythematosus. J Clin Lab Anal. 2019;33(1):e22633. https://doi.org/10.1002/jcla.22633

Ma L, Zeng A, Chen B, Chen Y, Zhou R. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with systemic lupus erythematosus and their correlation with activity: A meta-analysis. Int Immunopharmacol. 2019;76:105949. https://doi.org/10.1016/j.intimp.2019.105949

Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases. Ann Lab Med. 2019;39(4):345-357. https://doi.org/10.3343/alm.2019.39.4.345

Hao X, Li D, Wu D, Zhang N. The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis. Sci Rep. 2017;7(1):10833. https://doi.org/10.1038/s41598-017-11398-4

Maharani W, Ratnaningsih DF, Utami F, Yulianto FA, Dewina A, Hamijoyo L, Atik N. Activity Disease in SLE Patients Affected IFN-? in the IGRA Results. J Inflamm Res. 2020;13:433-439. https://doi.org/10.2147/jir.s258235

Ramirez GA, Manfredi AA, Maugeri N. Misunderstandings Between Platelets and Neutrophils Build in Chronic Inflammation. Front Immunol. 2019;10:2491. https://doi.org/10.3389/fimmu.2019.02491

Firizal AS, Sugianli AK, Hamijoyo L. Cut off point of neutrophil-to-lymphocyte ratio as a marker of active disease in systemic lupus erythematosus. Lupus. 2020;29(12):1566-1570. https://doi.org/10.1177/0961203320950822

Wu Y, Chen Y, Yang X, Chen L, Yang Y. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus. Int Immunopharmacol. 2016;36:94-9. https://doi.org/10.1016/j.intimp.2016.04.006

Li W, Liu S, Chen C, Han Y. Neutrophil-to-lymphocyte ratios and platelet-to-lymphocyte ratios in juvenile systemic lupus erythematosus: correlation with disease manifestations. Ann Palliat Med. 2021;10(9):9406-9414. https://doi.org/10.21037/apm-21-1995

Yang Z, Zhang Z, Lin F, Ren Y, Liu D, Zhong R, Liang Y. Comparisons of neutrophil-, monocyte-, eosinophil-, and basophil- lymphocyte ratios among various systemic autoimmune rheumatic diseases. APMIS. 2017;125(10):863-871. https://doi.org/10.1111/apm.12722

Descargas

Publicado

20-09-2024

Número

Sección

Artículos Originales

Artículos similares

1 2 > >> 

También puede {advancedSearchLink} para este artículo.

Artículos más leídos del mismo autor/a