DRESS syndrome associated with the consumption of allopurinol: case report
DOI:
https://doi.org/10.52379/mcs.v7i2.282Keywords:
Erythroderma, Pharmacoderma, Allopurinol, DRESS syndromeAbstract
DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) represents a severe pharmacoderma with different clinical and paraclinical manifestations secondary to a drug hypersensitivity reaction. Its exact incidence is unknown but it is estimated between 1 in 1,000 and 1 in 10,000 cases of exposure to associated drugs. It is characterized by extensive generalized dermatosis in conjunction with organic involvement, lymphadenopathy, eosinophilia, and atypical lymphocytosis. Commonly associated drugs include aromatic anticonvulsants, carbamazepine, sulfonamides, and allopurinol. By using the RegiSCORE score it is possible to confirm or rule out a suspected diagnosis. Treatment depends on the severity of presentation, including topical steroids up to systemic steroids of variable duration depending on clinical and biochemical response. Mortality rates of 10 to 20% are reported, with liver failure being the main cause of death in these patients. We present the case of a 71-year-old female patient who, after treatment with allopurinol, debuted with erythroderma secondary to DRESS Syndrome.
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Author Biographies
Louis Fernando Robles Fernandes, Instituto Mexicano del Seguro Social, México, México
Myrka Daniela Almeida Cabrera, Instituto Mexicano del Seguro Social, México, México
Erick Escorcia Martinez, Instituto Mexicano del Seguro Social, México, México
Diana Jessica Leyva Tenorio, Instituto Mexicano del Seguro Social
Evangelina Vargas Villegas, Instituto Mexicano del Seguro Social
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Copyright (c) 2023 Louis Fernando Robles Fernandes, Myrka Daniela Almeida Cabrera, Erick Escorcia Martinez, Diana Jessica Leyva Tenorio, Evangelina Vargas Villegas
This work is licensed under a Creative Commons Attribution 4.0 International License.
