Characteristics of retinal lesions in patients diagnosed with Ocular Toxoplasmosis who come to a reference center in ophthalmology in Paraguay.
DOI:
https://doi.org/10.52379/mcs.v7i1.264Keywords:
Ocular toxoplasmosis, Paraguay, OphthalmologyAbstract
Introduction: Toxoplasmosis is a parasitic disease, in Latin America the prevalence is relatively high, it is known that the disease is not only the most frequent cause of posterior uveitis, but also the main cause of uveitis itself. In Paraguay there are no published epidemiological data on it. Objective: To determine the characteristics of retinal lesions in patients diagnosed with ocular Toxoplasmosis. Methods: This study is observational, descriptive, cross-sectional, temporally retrospective, with non-probabilistic sampling of consecutive cases. It focused on patients diagnosed with Toxoplasmosis who attended the Ophthalmology service of the Hospital de Clínicas, during the period from June 2020 to February 2022. Results: 54.3% of women were observed, an average of 30.62 +/ - 12.96 years old and 62.8% of urban origin. 88.3% of the cases were unilateral, half were primary episodes, 93.6% acute cases, and 97.9% had an acquired transmission mechanism. Most presented as panuveitis, the most frequent locations of retinochoroidal lesions were the posterior pole (extramacular) and the periphery. The main therapeutic approach was treatment with trimethoprim sulfamethoxazole and systemic corticosteroids, the duration of treatment was 6.51 +/- 1.52 weeks, and the main complications were residual vitritis and ocular hypertension. Discussion: Ocular toxoplasmosis is an important cause of visual morbidity. It is essential to prevent infection by this parasite through hygienic-sanitary measures, as well as early diagnosis and treatment of infected patients, in order to reduce the complications associated with this pathology.
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References
Condori-Sarzuri V, Cruz-Ochoa JN, Loza-Murguia MG. Toxoplasmosis ocular. Una visión general durante el embarazo. Current Opinion Nursing & Research. 2020;2(2):26–38. URL.
Furtado JM, Winthrop KL, Butler NJ, Smith JR. Ocular toxoplasmosis I: parasitology, epidemiology and public health. Clin Exp Ophthalmol. 2013;41(1):82-94. https://doi.org/10.1111/j.1442-9071.2012.02821.x
Butler NJ, Furtado JM, Winthrop KL, Smith JR. Ocular toxoplasmosis II: clinical features, pathology and management: Ocular toxoplasmosis. Clin Experiment Ophthalmol. 2013;41(1):95–108. http://dx.doi.org/10.1111/j.1442-9071.2012.02838.x
Gonzalez Fernandez D, Nascimento H, Nascimento C, Muccioli C, Belfort R. Uveitis in São Paulo, Brazil: 1053 New Patients in 15 Months. Ocular Immunology and Inflammation. 2017;25(3):382–387. https://doi.org/10.3109/09273948.2015.1132741
Holland GN. Ocular toxoplasmosis: a global reassessment. Am J Ophthalmol. 2004;137(1):1–17. https://www.sciencedirect.com/science/article/pii/S0002939403013199
London NJ, Hovakimyan A, Cubillan LD, Siverio CD Jr, Cunningham ET Jr. Prevalence, clinical characteristics, and causes of vision loss in patients with ocular toxoplasmosis. Eur J Ophthalmol. 2011;21(6):811-819. https://doi.org/10.5301/EJO.2011.6403
Bosch-Driessen LE, Berendschot TT, Ongkosuwito JV, Rothova A. Ocular toxoplasmosis: clinical features and prognosis of 154 patients. Ophthalmology. 2002;109(5):869-878. https://doi.org/10.1016/s0161-6420(02)00990-9
Arantes TE, Silveira C, Holland GN, Muccioli C, Yu F, Jones JL, Goldhardt R, Lewis KG, Belfort R Jr. Ocular Involvement Following Postnatally Acquired Toxoplasma gondii Infection in Southern Brazil: A 28-Year Experience. Am J Ophthalmol. 2015;159(6):1002-1012.e2. https://doi.org/10.1016/j.ajo.2015.02.015
Grigg ME, Dubey JP, Nussenblatt RB. Ocular toxoplasmosis: lessons from Brazil. Am J Ophthalmol. 2015;159(6):999-1001. https://doi.org/10.1016/j.ajo.2015.04.005
Fernandes LC, Orefice F. Aspectos clinicos e epidemiologicos das uveites, em servicos de referencia em Belo Horizonte 1970–1993, parte I. Rev Bras Oftal 1996; 55:569–78. URL.
Holland GN, Lewis KG. An update on current practices in the management of ocular toxoplasmosis1, 2. American Journal of Ophthalmology. el 1 de julio de 2002;134(1):102–114. https://doi.org/10.1016/S0002-9394(02)01526-X
Garza-Leon M, Arellanes Garcia L. Ocular toxoplasmosis: Clinical characteristics in pediatric patients. Ocul Immunol Inflamm. 2012;20(2):130–8.: http://dx.doi.org/10.3109/09273948.2012.656878
Panek WC, Holland GN, Lee DA, Christensen RE. Glaucoma in patients with uveitis. Br J Ophthalmol. 1990;74(4):223-227. https://doi.org/10.1136/bjo.74.4.223
Fardeau C, Romand S, Rao NA, Cassoux N, Bettembourg O, Thulliez P, Lehoang P. Diagnosis of toxoplasmic retinochoroiditis with atypical clinical features. Am J Ophthalmol. 2002;134(2):196-203. https://doi.org/10.1016/s0002-9394(02)01500-3
Holland GN. Reconsidering the pathogenesis of ocular toxoplasmosis. Am J Ophthalmol. 1999;128(4):502-5. https://doi.org/10.1016/s0002-9394(99)00263-9
Arruda S, Vieira BR, Garcia DM, Araújo M, Simões M, Moreto R, Rodrigues MW Jr, Belfort R Jr, Smith JR, Furtado JM. Clinical manifestations and visual outcomes associated with ocular toxoplasmosis in a Brazilian population. Sci Rep. 2021;11(1):3137. https://doi.org/10.1038/s41598-021-82830-z
Colombero D, Gasperi C, Ladeveze E, Ortiz A, Useglio M, Villalobos A. Toxoplasmosis Ocular: Manifestaciones clínicas en 93 pacientes. Archivos Argentinos de Oftalmologia. 2016;6:31–38. URL.
Panek WC, Holland GN, Lee DA, Christensen RE. Glaucoma in patients with uveitis. Br J Ophthalmol. 1990;74(4):223–227. http://dx.doi.org/10.1136/bjo.74.4.223
Fardeau C, Romand S, Rao NA, Cassoux N, Bettembourg O, Thulliez P, et al. Diagnosis of toxoplasmic retinochoroiditis with atypical clinical features. Am J Ophthalmol. 2002;134(2):196–203. http://dx.doi.org/10.1016/s0002-9394(02)01500-3
Grandía G. R, Entrena G. Á, Cruz H. J. Toxoplasmosis en Felis catus: etiología, epidemiología y Enfermedad. Revista de Investigaciones Veterinarias del Perú. 2013;24(2):131–49. URL.
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