Implications of new diagnostic criteria for obesity on mental health comorbidities

Authors

  • Julio Torales Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Grupo de Investigación sobre Epidemiología de los Trastornos Mentales, Psicopatología y Neurociencias, San Lorenzo, Paraguay
  • Marcelo O'Higgins Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Grupo de Investigación sobre Epidemiología de los Trastornos Mentales, Psicopatología y Neurociencias, San Lorenzo, Paraguay.
  • Tomás Caycho-Rodríguez Universidad Científica del Sur, Lima, Perú.
  • Antonio Ventriglio University of Foggia, Department of Clinical and Experimental Medicine, Foggia, Italy.
  • João Mauricio Castaldelli-Maia 6 University of São Paulo, Department of Psychiatry, São Paulo, SP, Brazil.
  • Iván Barrios Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Cátedra de Metodología de la Investigación, Santa Rosa del Aguaray, Paraguay

DOI:

https://doi.org/10.52379/mcs.v10.767

Abstract

A recent report published by The Lancet Diabetes & Endocrinology Commission entitled Definition and diagnostic criteria of clinical obesity (2025) represents a major conceptual shift in how obesity is defined and understood. Moving beyond the long-standing reliance on body mass index (BMI), the Commission proposes a framework that conceptualizes obesity as a multifactorial, chronic, and systemic disease, emphasizing its functional, metabolic, and organ-specific consequences rather than body size alone. This reconceptualization has profound implications not only for medical practice but also for mental health research and care.

For decades, BMI has served as the primary diagnostic proxy for obesity despite well-documented limitations. BMI does not capture body composition, fat distribution, metabolic heterogeneity, or psychosocial burden. Individuals with elevated BMI may present preserved physical and mental functioning, whereas others with lower BMI values may experience marked psychological distress and functional impairment related to adiposity. Consequently, the exclusive use of BMI has often obscured clinically meaningful subgroups and contributed to both underdiagnosis and overmedicalization.

By prioritizing disease impact over numerical thresholds, the concept of “clinical obesity” allows for a more nuanced understanding of obesity and its associated comorbidities. Importantly, this shift provides a valuable opportunity to integrate mental health more explicitly into obesity assessment and management, acknowledging that psychological distress may be both a consequence and a constituent dimension of the disease.

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References

1. Rubino F, Cummings DE, Eckel RH, Cohen RV, Wilding JPH, Brown WA, et al. Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol. 2025;13(3):221-262. https://doi.org/10.1016/S2213-8587(24)00316-4. Erratum in: Lancet Diabetes Endocrinol. 2025;13(3):e6. https://doi.org/10.1016/S2213-8587(25)00006-3

2. Simon GE, Von Korff M, Saunders K, Miglioretti DL, Crane PK, van Belle G, Kessler RC. Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry. 2006;63(7):824-30. https://doi.org/10.1001/archpsyc.63.7.824

3. Scott KM, Bruffaerts R, Simon GE, Alonso J, Angermeyer M, de Girolamo G, et al. Obesity and mental disorders in the general population: results from the world mental health surveys. Int J Obes (Lond). 2008;32(1):192-200. https://doi:org/10.1038/sj.ijo.0803701

4. Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67(3):220-9. https://doi.org/10.1001/archgenpsychiatry.2010.2

5. Faith MS, Butryn M, Wadden TA, Fabricatore A, Nguyen AM, Heymsfield SB. Evidence for prospective associations among depression and obesity in population-based studies. Obes Rev. 2011;12(5):e438-53. https://doi.org/10.1111/j.1467-789X.2010.00843.x

6. van Strien T. Causes of Emotional Eating and Matched Treatment of Obesity. Curr Diab Rep. 2018;18(6):35. https://doi.org/10.1007/s11892-018-1000-x

7. Milaneschi Y, Simmons WK, van Rossum EFC, Penninx BW. Depression and obesity: evidence of shared biological mechanisms. Mol Psychiatry. 2019;24(1):18-33. https://doi.org/10.1038/s41380-018-0017-5

8. Mansur RB, Brietzke E, McIntyre RS. Is there a "metabolic-mood syndrome"? A review of the relationship between obesity and mood disorders. Neurosci Biobehav Rev. 2015;52:89-104. https://doi.org/10.1016/j.neubiorev.2014.12.017.

9. Tomiyama AJ. Stress and Obesity. Annu Rev Psychol. 2019;70:703-718. https://doi.org/10.1146/annurev-psych-010418-102936

10. Puhl RM, Heuer CA. The stigma of obesity: a review and update. Obesity (Silver Spring). 2009;17(5):941-64. https://doi.org/10.1038/oby.2008.636

11. Pearl RL. Weight bias and stigma: public health implications and structural solutions. Soc Issues Policy Rev. 2018;12(1):146–182. https://doi.org/10.1111/sipr.12043

12. Pearl RL, Puhl RM, Himmelstein MS, Pinto AM, Foster GD. Weight Stigma and Weight-Related Health: Associations of Self-Report Measures Among Adults in Weight Management. Ann Behav Med. 2020;54(11):904-914. https://doi.org/10.1093/abm/kaaa026

13. Sharma AM, Campbell-Scherer DL. Redefining obesity: Beyond the numbers. Obesity (Silver Spring). 2017;25(4):660-661. https://doi.org/10.1002/oby.21801

14. Bray GA, Heisel WE, Afshin A, Jensen MD, Dietz WH, Long M, et al. The Science of Obesity Management: An Endocrine Society Scientific Statement. Endocr Rev. 2018;39(2):79-132. https://doi.org/10.1210/er.2017-00253

15. Topol EJ. Individualized medicine from prewomb to tomb. Cell. 2014;157(1):241-53. https://doi.org/10.1016/j.cell.2014.02.012

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Published

02/01/2026

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Editorial

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